' 
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Medium or Average
Based on 4 Reviews
6.2
Supplement Facts
Serving Size: 2 capsules
Amount Per Serving
%DV
Vitamin C (from culture of Saccharomyces cerevisiae)
500 mg
556%
Raw Organic Fruit & Vegetable Blend
720 mg
+
Raw Probiotic & Enzyme Blend
60 mg
+
Top Medical Research Studies
7
Vitamin C's uncertain heart benefits
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1.
Relevant discussion on vitamin C
We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
Read More
8
Nutrition's role in heart health
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.
Focus on vitamin C effectiveness
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Vitamin C's role in heart health
Role of ascorbic acid in cardiac allograft vasculopathy.
Relevant to cardiac care research
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Read More
Most Useful Reviews
9.5
Boosts heart health
Excellent! This vitamin C is the best on iHerb. All vitamins from this brand include probiotics, which are especially beneficial for those aged 40-50. They are completely natural and 100% digestible. I immediately feel more energised and it protects against viruses. For collagen and heart disease, I take it daily with my husband. We have tried various vitamin C supplements, but we will only purchase this one from now on.
Read More
8.8
Mild illness experienced
I noticed the effect! After taking these vitamins for a month, I caught the flu, but my illness was surprisingly mild. During the initial days, I took 1g, or four capsules. My husband, who did not take vitamins, suffered through the illness for more than a week, but with vitamin C, my experience was much easier.
Read More
0
Misleading description noted
The original description on the site misleads buyers. This Vitamin Code Raw C is advertised as a potent antioxidant and crucial for collagen production; however, it cannot be deemed raw or natural after being processed through yeast fermentation. Despite its apparent economic value and the claim of being beneficial for age-related issues including heart disease, the product’s actual preparation contradicts the description. I cannot recommend buying Vitamin Code Raw C from Garden of Life.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
- All Researches
9
Vitamin C's potential in heart health
Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats.
Combination treatment assessed
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
Read More
8
Nutrition's role in heart health
Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.
Focus on vitamin C effectiveness
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Combined antioxidants may benefit heart
Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.
Limited isolated effect of vitamin C
We explored the potential of a combined antioxidant therapy that includes vitamin C to address myocardial reperfusion injury—a condition that can worsen heart damage after blood flow is restored following ischemia. In a Phase 1 clinical trial involving healthy participants, we tested whether this therapy could be safely administered while also examining the effects on oxidative stress, a key factor in heart injury.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
Read More
8
BM-164 shows heart-protective effects
Effects of HS-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts.
Vitamin C's isolated effects unclear
We explored the effects of a novel water-soluble derivative of ascorbic acid, known as BM-164, on heart health under conditions of ischemia and reperfusion in rat hearts. This study aimed to combine the cardiovascular benefits of hydrogen sulfide (HS) with the antioxidant properties of ascorbic acid.
Through a series of tests, we found that BM-164 significantly reduced the incidence of harmful heart rhythms known as ventricular fibrillation from 79% to 31%. Moreover, the size of heart tissue damage, often referred to as infarct size, was decreased from 28% to 14% in the group treated with BM-164.
However, we also noted that while heart function improvements, such as coronary flow and heart rate, didn't show significant differences compared to a drug-free control group. Further analysis of cellular processes revealed increased levels of autophagy-related proteins, which could explain the heart-protective effects of BM-164, while markers of apoptosis didn’t show notable changes.
In conclusion, BM-164 showcases considerable potential in providing cardiac protection during injury caused by ischemia and reperfusion, showing advantages over untreated and simply ascorbic acid-treated hearts.
Through a series of tests, we found that BM-164 significantly reduced the incidence of harmful heart rhythms known as ventricular fibrillation from 79% to 31%. Moreover, the size of heart tissue damage, often referred to as infarct size, was decreased from 28% to 14% in the group treated with BM-164.
However, we also noted that while heart function improvements, such as coronary flow and heart rate, didn't show significant differences compared to a drug-free control group. Further analysis of cellular processes revealed increased levels of autophagy-related proteins, which could explain the heart-protective effects of BM-164, while markers of apoptosis didn’t show notable changes.
In conclusion, BM-164 showcases considerable potential in providing cardiac protection during injury caused by ischemia and reperfusion, showing advantages over untreated and simply ascorbic acid-treated hearts.
Read More
8
Vitamin C's role in heart health
Role of ascorbic acid in cardiac allograft vasculopathy.
Relevant to cardiac care research
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 4 Reviews
6.2
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Boosts heart health
Excellent! This vitamin C is the best on iHerb. All vitamins from this brand include probiotics, which are especially beneficial for those aged 40-50. They are completely natural and 100% digestible. I immediately feel more energised and it protects against viruses. For collagen and heart disease, I take it daily with my husband. We have tried various vitamin C supplements, but we will only purchase this one from now on.
Read More
8.8
Mild illness experienced
I noticed the effect! After taking these vitamins for a month, I caught the flu, but my illness was surprisingly mild. During the initial days, I took 1g, or four capsules. My husband, who did not take vitamins, suffered through the illness for more than a week, but with vitamin C, my experience was much easier.
Read More
0
Misleading description noted
The original description on the site misleads buyers. This Vitamin Code Raw C is advertised as a potent antioxidant and crucial for collagen production; however, it cannot be deemed raw or natural after being processed through yeast fermentation. Despite its apparent economic value and the claim of being beneficial for age-related issues including heart disease, the product’s actual preparation contradicts the description. I cannot recommend buying Vitamin Code Raw C from Garden of Life.
Read More
0
Caused kidney pain
It caused me kidney pain while I was taking it. After I stopped, the pain eased.
